Copper Tripeptide-1: Properties and Cosmetic Applications
What Is Copper Tripeptide-1?
Copper Tripeptide-1 (Cu-GHK) was one of the first peptides used in cosmetics for topical skin applications. It is a copper complex of the tripeptide GHK (glycyl-L-histidyl-L-lysine) and resembles a sequence found in the alpha chain of collagen.
How Does Copper Tripeptide-1 Work?
Copper Tripeptide-1 is classified as a carrier peptide and has been investigated for its effects on several processes involved in skin structure and repair.
Studies have associated Cu-GHK with stimulation of:
- Collagen synthesis
- Glycosaminoglycan synthesis
- Elastin synthesis
- Proteoglycan synthesis
- Fibroblast activity
It has also been investigated for its potential anti-inflammatory effects and its role in supporting the skin barrier.
Copper Tripeptide-1 in Skincare
Copper Tripeptide-1 is used in cosmetic formulations targeting the visible signs of skin ageing. Its applications include products formulated to improve the appearance of:
- Fine lines and wrinkles
- Hyperpigmentation
- Photoaged skin
- Loss of firmness
It has also been studied in relation to keratinocyte proliferation and epidermal repair.
References
Journal of Drug Delivery Science and Technology – Anti-aging peptides for advanced skincare: Focus on nanodelivery systems
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